کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8270539 | 1534971 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice
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کلمات کلیدی
GSHKDHeNOSRNSiNOSLPSIL-6ROS - ROSAntioxidant - آنتی اکسیدانα-Lipoic acid - اسید α-لیپوئیکinterleukin-6 - اینترلوکین ۶tumor necrosis factor α - تومور نکروز عامل αFree radicals - رادیکال آزادinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالTNF-α - فاکتور نکروز توموری آلفاLipoic acid - لیپوئیک اسیدlipopolysaccharide - لیپوپلی ساکاریدα-ketoglutarate dehydrogenase complex - مجتمع α-کتوگلووترات دی هیدروژنازMitochondria - میتوکندریاwild type - نوع وحشیGlutathione - گلوتاتیونreactive nitrogen species - گونه های واکنش پذیر نیتروژنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypothermia is a key symptom of sepsis, but the mechanism(s) leading to hypothermia during sepsis is largely unknown and thus no effective therapy is available for hypothermia. Therefore, it is important to investigate the mechanism and develop effective therapeutic methods. Lipopolysaccharide (LPS)-induced hypothermia accompanied by excess nitric oxide (NO) production leads to a reduction in energy production in wild-type mice. However, mice lacking inducible nitric oxide synthase did not suffer from LPS-induced hypothermia, suggesting that hypothermia is associated with excess NO production during sepsis. This observation is supported by the treatment of wild-type mice with α-lipoic acid (LA) in that it effectively attenuates LPS-induced hypothermia with decreased NO production. We also found that LA partially restored ATP production, and activities of the mitochondrial enzymes involved in energy metabolism, which were inhibited during sepsis. These data suggest that hypothermia is related to mitochondrial dysfunction, which is probably compromised by excess NO production and that LA administration attenuates hypothermia mainly by protecting mitochondrial enzymes from NO damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 71, June 2014, Pages 362-367
Journal: Free Radical Biology and Medicine - Volume 71, June 2014, Pages 362-367
نویسندگان
Sylvia Hiller, Robert DeKroon, Longquan Xu, Jennifer Robinette, Witold Winnik, Oscar Alzate, Stephen Simington, Nobuyo Maeda, Xianwen Yi,