Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines

► Specific nitrones have been shown to have potent therapeutic potential. ► Nitrone OKN-007 has potent anti-cancer activity in glioblastoma models. ► Lanthionine ethyl ester had anti-cancer activity in a glioblastoma model. ► Combining a nitrone and lanthionine has enhanced therapeutic potential. ► Nitrones show potential for treating dementia in aging, sepsis, and malaria infection.