Strategies for the analysis of chlorinated lipids in biological systems

► Myeloperoxidase-derived HOCl oxidation of plasmalogens yields chlorinated lipids. ► α-Chlorofatty aldehydes derivatized to pentafluorobenzyl oximes can be identified by GC-MS. ► α-Chlorofatty acids can be identified by LC-MS. ► 2-Chloroadipic acid excreted in the urine can be identified by LC-MS.