Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients

► We demonstrate the effects of hemodialysis on steady-state nitrite and nitrate levels. ► Disruption of the enterosalivary circulation of nitrate may lead to a loss of NO activity. ► Loss of plasma and salivary nitrite and nitrate may have negative health outcomes. ► This study provides new considerations for anion repletion in dialysis patients.