High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair

► Chlorinated and nitrated HDL have reduced capacity to stimulate endothelial cell (EC) proliferation. ► Cl-HDL and NO2-HDL have reduced capacity to stimulate EC migration. ► Cl-HDL and NO2-HDL have diminished capacity to activate Akt and ERK1/2 in ECs. ► Cl-HDL and NO2-HDL show reduced stimulation of reendothelialization in vivo.