کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8284671 | 1535580 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of heterochromatin stability on intestinal stem cell aging in Drosophila
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کلمات کلیدی
JnkH3K9me3TORDIAP1H3K9me2RHEBPH3phosphorylated histone H3HP14EBPc-Jun N-terminal kinase - C-Jun N-terminal kinaseAkt - آکتEnterocyte - انتروسیRas homolog enriched in brain - رایحه همولوگ در مغز غنی شده استintestinal stem cell - سلول های بنیادی رودهphosphatase and tensin homolog - فسفاتاز و تنسین همولوگDrosophila - مگس سرکهtarget of rapamycin - هدف از رپامایسینheterochromatin protein 1 - پروتئین هتروکروماتین 1protein kinase B - پروتئین کیناز BPten - ژن PTEN
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of heterochromatin stability on intestinal stem cell aging in Drosophila Effect of heterochromatin stability on intestinal stem cell aging in Drosophila](/preview/png/8284671.png)
چکیده انگلیسی
Chromatin change is one of the crucial causes of aging. Specifically, maintenance of heterochromatin stability is critical for cellular integrity, and its loss induces genomic instability and cellular aging. However, the causes and effects of heterochromatin instability in multicellular tissue aging still remain unclear. Here, in the adult Drosophila midgut, we report age-related loss of heterochromatin stability in enterocytes (ECs) due to the loss and dispersion of tri-methylated histone H3 Lys9 (H3K9me3) and heterochromatin protein 1 (HP1). Our study further shows that EC-specific knockdown of Su(var)3-9, histone lysine methyltransferase for H3K9me3 formation, or HP1a leads to intestinal stem cell (ISC) aging through genomic stress, JNK signaling, and apoptotic death in ECs. Our findings revealed the plausible causes of age-related loss of heterochromatin stability in ECs, including oxidative stress and nutrient-sensing AKT/TOR signaling. Taken together, the loss of heterochromatin stability may be the crucial niche aging mechanism for ISC aging which is the prime determinant of intestinal tissue aging. Furthermore, our study provides new clues on the link between heterochromatin and aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 173, July 2018, Pages 50-60
Journal: Mechanisms of Ageing and Development - Volume 173, July 2018, Pages 50-60
نویسندگان
Ho-Jun Jeon, Young-Shin Kim, Joong-Gook Kim, Kyu Heo, Jung-Hoon Pyo, Masamitsu Yamaguchi, Joung-Sun Park, Mi-Ae Yoo,