Keywords: mTOR; Rheb; Dendrite; Focal cortical dysplasia;
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Keywords: KME; aqueous extract of Korean mistletoe; EMG; electromyography; FoxO1; forkhead box protein O1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3; glycogen synthase kinase 3; IGF; insulin growth factor; IR; insulin receptor; IRS1; insulin receptor su
Keywords: CAPRI; Ca2+-promoted RAS inactivator; CRMP-2; collapsin response mediator protein-2; CSRD; cysteine/serine-rich domain; CTD; C-terminal domain; ERK; extracellular signal-regulated kinase; FTI; farnesyltransferase inhibitor; FAK1; focal adhesion kinase 1;
Keywords: Dlco; diffusing capacity of the lung for carbon monoxide; GTP; guanosine triphosphate; GTPase; guanosine triphosphatase; LAM; lymphangioleiomyomatosis; mTOR; mechanistic target of rapamycin; Rheb; Ras homolog enriched in brain; TSC; tuberous sclerosis com
Keywords: ACLY; ATP citrate lyase; AKT; protein kinase B; ATP; adenosine triphosphate; ANT; adenine nucleotide translocator; AMPK; AMP-activated protein kinase; COX; cytochrome c oxidase; EGFR; epidermal growth factor receptor; ERRα; estrogen-related receptor alph
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy
Keywords: Akt; protein kinase B; Ambra1; Autophagy And Beclin 1 Regulator 1; AMPK; 5â² AMP-activated protein kinase; Atg; autophagy related proteins; CAMKK; Ca2+/calmodulin-dependent protein kinase kinase; DFCP1; double FYVE-containing protein 1; DPP4; dipeptidyl
eIF4E Phosphorylation in Prostate Cancer
Keywords: eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP
Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI
Keywords: AAV2; adeno-associated virus serotype-2; C2 (3, 4, 5, etc.); cervical spinal cord level 2 (3, 4, 5, etc.); CMAP; compound muscle action potential; CNS; central nervous system; CTB; cholera toxin subunit B; EMG; electromyography; GAP; GTPase-activating pro
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling
Keywords: Akt; AKT serine/threonine kinase 1; BCA; bicinchoninic acid; BRAF; B-Raf proto-oncogene, serine/threonine kinas; COX-2; cyclooxygenase-2; CUR; curcumin; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; eEF2; eukaryotic translati
MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation
Keywords: BMM; bone marrow-derived macrophages; M-CSF; macrophage-colony stimulating factor; miR; microRNA; miR-155; microRNA-155; MNC; multinucleated cells; OC; osteoclast; PBS; phosphate-buffered saline; qPCR; quantitative polymerase chain reaction; RANKL; recept
Effect of heterochromatin stability on intestinal stem cell aging in Drosophila
Keywords: H3K9me3; tri-methyl histone H3 lysine9; H3K9me2; di-methyl histone H3 lysine9; HP1; heterochromatin protein 1; Su(var)3-9; suppressor of variegation 3-9; γH2AvD; phosphorylated Drosophila histone variant of H2A (Ser137); PH3; phosphorylated histone H3; J
Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1α mediated signal pathway
Keywords: DHTS; dihydrotanshinone I; LCFAs; long-chain fatty acids; PTEN; phosphatase and tensin homolog gene; HIF1α; hypoxia inducible factor 1 alpha; HKII; hexokinase II; p-AKT; phosphorylated protein kinase B; RHEB; Ras homolog enriched in brain; SIRT3; Silent
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
The characterization of RHEB gene and its responses to hypoxia and thermal stresses in the small abalone Haliotis diversicolor
Keywords: Haliotis diversicolor; RHEB; NF-κB pathway; Hypoxia; Thermal;
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice
Keywords: Rheb; Forebrain; BACE1; Spatial memory; Alzheimer's disease;
A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM
Keywords: TCGA; The Cancer Genome Atlas; LIMMA; Linear Models for Microarray data; DEGs; differentially expressed genes; SVM; support vector machine; d-CEA; draining venous blood; GEO; Gene Expression Omnibus; RMA; Robust Multichip Average; RFE; recursive feature e
The role of the TOR pathway in mediating the link between nutrition and longevity
Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m
Molecular neurobiology of mTOR
Keywords: 4E-BPs; 4E-binding proteins; Atg13; autophagy-related protein 13; BDNF; brain-derived neurotrophic factor; CGG; trinucleotide; EGF; epidermal growth factor; FXS; Fragile X syndrome; Hif1α; hypoxia-inducible factor 1-α; LTD; long-term depression; LTP; lo
Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b
Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR
Keywords: AMPK; AMP-activated protein kinase; IGF; insulin-like growth factor; PI3K; phosphoinositide 3-kinase; RHEB; RAS homolog enriched in brain; TOR; target of rapamycin; TORC; TOR complex; TSC1/2; tuberous sclerosis 1 and 2; Invertebrate; TOR; Longevity; Rapam
Decorin as a multivalent therapeutic agent against cancer
Keywords: AMPKα; AMP-activated protein kinase, alpha; AP4; Activating enhancer binding protein 4; ATG; Autophagy-related gene; Bcl2; B-cell CLL/lymphoma 2; BRAF; Proto-oncogene B-Raf; ECM; Extracellular matrix; EGFR; Epidermal growth factor receptor; ERK; Extracel
NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors
Keywords: Rheb; mTOR signaling pathway; Neurotrophin-3 (NT-3); Axonal regeneration; Dorsal root ganglion (DRG);
Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner
Keywords: HIF; Hypoxia-inducible Factor; IL-6; Interleukin 6; IRS1; Insulin Receptor Substrate 1; Jak; Januskinase; mTOR; Mammalian Target of Rapamycin; MEF; Mouse Embryonic Fibroblast; NF-κB; Nuclear Factor kappa B; n.s.; non-significant; MAPK; Mitogen-Activated
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; AMP-activated protein kinase; Atg13; autophagy-related 13; FIP200; 200Â kilodalton focal adhesion kinase family kinase-interacting protein; GAP; GTPase activator protein; GATOR; GAP activity
Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation
Keywords: Mammalian target of rapamycin; Hippocampus; Kaplan-Meier; Forebrain-specific Tsc2 Knock-out; mTOR overactivation; mTORC; mechanistic Target of Rapamycin Complex; Rheb; Ras-homolog enriched in brain; S6; ribosomal protein S6; S6K; ribosomal protein S6 ki
Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway
Keywords: 4E-BP; eukaryotic translation initiation factor 4E-binding protein; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AMPK; 5â² AMP-activated protein kinase; EBs; enteroblasts; ECs; enterocytes; EEs; enteroendocrine cells; EGFR; epidermal growth factor receptor; IGF1
Regulation of mTORC1 by PI3K signaling
Keywords: insulin; TSC2; Rheb; Rag; Raptor; lysosome
Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components
Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity
Keywords: Mitophagy; Proinflammatory response; Rheb; KIF5BHFD, high-fat diet; BMM, bone marrow-derived macrophage; MCP-1, monocyte chemotactic protein-1; PA, palmitic acid; T2D, type 2 diabetes; ROS, reactive oxygen species; Lamp, lysosome-associated membrane prote
Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes
Keywords: AMPK; AMP-activated protein kinase; CHOP; C/EBP homologous protein; 4E-BP1; eukaryotic initiation factor 4E (eIF4E) binding protein 1; EPA; eicosapentaenoic acid; ER; endoplasmic reticulum; FFA; free fatty acid; HEK293; human embryonic kidney cell line 29
Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: Cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis
Keywords: Target of rapamycin; Rheb; Akt; p70 S6 kinase; Molting; Crustacea; Y-organ; Ecdysteroid
mTOR signaling in tumorigenesis
Keywords: mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration
Keywords: AVP; arginine vasopressin; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; PI3K; phosphatidyl inositol-3 kinase; AMPK; AMP-activated protein kinase; PKC; protein kinase C, Akt or protein kinase B; TSC1/TSC2; tubero sclerosis protein 1 and 2;
Fisetin regulates obesity by targeting mTORC1 signaling
Keywords: mTORC1; mammalian target of rapamycin complex 1; S6K1; 70-kDa ribosomal protein S6 kinase 1; TSC2; tuberous sclerosis protein 2; HFD; high-fat diet; PPAR-γ; peroxisome proliferator-activated receptor γ; SREBP-1; sterol regulatory element-binding protein
Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration
Keywords: TSC; tuberous sclerosis; mTOR; mammalian target of rapamycin; GAP; GTPase-activating protein; MAPK; mitogen-activated protein kinase; p90 RSK; p90 ribosomal S6 kinase; ERK; extracellular signal-regulated kinase; P70S6K; p70 ribosomal S6 kinase; AMPK; 5â²
Upregulation of Ras homolog enriched in the brain (Rheb) in lipopolysaccharide-induced neuroinflammation
Keywords: Lipopolysaccharide; Rheb; Neuroinflammation; Astrocyte; Neuron; Rat
Deacetylated αβ-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading
Keywords: Rheb; Soluble tubulin; mTOR; Mitosis
β-Arrestin signal complex plays a critical role in adipose differentiation
Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy
Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ÎRG mouse model of tuberous sclerosis complex
Keywords: 4E-BP; eIF4E binding protein; ACSF; artificial cerebrospinal fluid; CMV; cytomegalovirus; FXS; fragile X syndrome; GAP; GTPase-activating protein; GDP; guanosine diphosphate; GTP; guanosine triphosphate; mTORC1; mammalian target of rapamycin complex 1; Rh
Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation
Keywords: Type 1 diabetes; NOD; Rheb; mTOR; CFA; GLP-1
Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease
Keywords: Huntington's disease; Polyglutamine diseases; Striatal physiology; Medium-size spiny neurons; Interneurons; ATF6α; Small GTPases; Rheb; Cell cycle re-entry; Cyclin E
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization
Keywords: mTORC1; mammalian target of rapamycin complex 1; ECM; extracellular matrix; S6K1; S6 kinase 1; Rb; retinoblastoma protein; REF; rat embryonic fibroblast; Eker REF; Eker (Tsc2â/â) rat embryonic fibroblast; 4EBP; eIF4E binding protein; ALLN; N-acetyl-le
Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction
Keywords: TSC; tuberous sclerosis complex; RHEB; ras homolog expressed in brain; TORC1; target of rapamycin complex 1; S6K; p70 S6 kinase; GAP; GTPase activating protein; Tuberous sclerosis complex; TSC1; TSC2; TORC1;