کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8284844 1535604 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum copper to zinc ratio: Relationship with aging and health status
ترجمه فارسی عنوان
نسبت مس به روی نسبت سرم: رابطه با وضعیت پیری و سلامت
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
The serum concentrations of copper (Cu) and zinc (Zn) are strictly regulated by compensatory mechanisms that act to stabilize them within certain ranges of nutritional intake. However, there are mechanisms that are built to decrease serum concentration of Zn and to increase serum concentration of Cu in the presence of inflammatory conditions, so that a common feature of several age-related chronic diseases is an increase of the Cu to Zn ratio (CZr). Although the clinical potential of CZr has been extensively investigated, few authors addressed the mechanisms that mainly contribute to the increase of CZr in serum during aging, which signals drive this change and how cells respond to these changes. This review focuses on this topic and discusses how an increase of CZr during aging could reflect the homeostatic shade from a general systemic “growth and reproduction” status typical of juvenile age to a “repair and maintenance” status that evolved to preserve health status during old age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 151, November 2015, Pages 93-100
نویسندگان
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