کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8285066 1535624 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans
چکیده انگلیسی
► The temperature dependency of the lifespan of age-1 and eat-2 mutants was normal. ► The temperature dependency of daf-2 mutants was apparently abnormal. ► The abnormality of daf-2 mutants could be explained from a view of protein denaturation. ► The onset of demographic aging appears to be genetically determined through the insulin/IGF-1 signaling pathway. ► We conclude that the onset timing of aging and death appears to be different.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 133, Issues 9–10, September–October 2012, Pages 600-610
نویسندگان
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