Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium

► Sirtuins play a role on aging in a natural low-nitrogen and high-sugar growth medium. ► Sir2p and Hst2p role on aging depends on the growth medium used. ► Gcn5p is necessary for aldehyde dehydrogenase autophagy during nitrogen starvation. ► Autophagy shortens life span during grape juice fermentation. ► Partial TOR inhibition extends chronological life span through Gcn5p.