Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism

► Aging is associated with decreased arterial AMPK expression. ► Short-term pharmacological AMPK activation with AICAR ameliorates age-associated vascular endothelial dysfunction by reducing oxidative stress. ► AMPK activation is a potential therapy for treating arterial aging and reducing cardiovascular disease risk.