Differences in the accumulation of mitochondrial defects with age in mice and humans

► Colonic and ciliary epithelial cells accumulate mitochondrial defects with age in mice and humans. ► Human colonic epithelium is more affected with age than mouse colonic epithelium. ► Mouse ciliary epithelium is more affected with age than human ciliary epithelium. ► There are species and tissue specific differences in mitochondrial defects with age.