Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling

► Inhibition of c-Met increases cisplatin efficacy against osteosarcoma. ► Inhibition of c-Met suppression of the PI3K-Akt signaling. ► Inhibition of Akt is mainly responsible for the effect of inhibition of c-Met.