The antioxidant phenylaminoethyl selenide reduces doxorubicin-induced cardiotoxicity in a xenograft model of human prostate cancer

► The effect of the antioxidant phenylaminoethyl selenide (PAESe) on doxorubicin (DOX)-mediated cardiotoxicity was determined. ► PAESe reduced evidence of DOX cardiotoxicity and weight loss in a prostate cancer xenograft model. ► PAESe reduced the formation of reactive oxygen species by DOX or by tert-butylhydroperoxide in human prostate cancer cells. ► PAESe did not decrease DOX antitumor activity in a prostate cancer xenograft model.