Activation of the PI3K/Akt signaling pathway through P2Y2 receptors by extracellular ATP is involved in osteoblastic cell proliferation

► ATP stimulates PI3K/Akt pathway in osteoblastic cell through P2Y2 receptors. ► PI-PLC, Ca2+, CaM and Src participate in Akt stimulation. ► PKC seems to regulate Akt through Src and the Ca2+ influx/CaM pathway. ► PI3K/Akt activation by ATP is involved in osteoblastic cell proliferation.