Protein phosphatases: Possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation

► Protein phosphatases as bisphosphonate targets in osteoblasts. ► Protein phosphatases are possible bisphosphonate binding sites. ► Bisphosphonates stimulate osteoblast proliferation through protein tyrosine phosphatase inhibition. ► Protein tyrosine phosphatase may be involved in the stimulatory action of bisphosphonates on osteoblast proliferation.