Prostaglandin E2 modulates proximal tubule Na+-ATPase activity: Cooperative effect between protein kinase A and protein kinase C

► PGE2 modulates sodium transporter in proximal tubule. ► PGE2 effect on PT Na+-ATPase activity involves G-protein. ► PKA-mediated PGE2 effect requires previous activation of PKC. ► PGE2 stimulates iPLA2 activity representing an important positive feedback.