Stimulation of mechano-growth factor expression by second messengers

► cAMP stimulates MGF expression in mouse myoblasts and myotubes. ► Both cAMP and PMA stimulate MGF expression in human myoblasts and myotubes. ► cAMP and PMA show some additivity of their effects and demonstrate different kinetics. ► cAMP and PMA stimulate MGF expression via two independent pathways. ► cAMP stimulates MGF expression via PKA activation.