Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

► Phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is involved in Tat-induced NADPH oxidase stimulation. ► NF-κB nuclear translocation in Tat-treated MAGI cells is dependent on Nox2 activation. ► Akt/NADPH oxidase pathway is involved in Tat-induced LTR transactivation in MAGI cells.