کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8292362 1536729 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sodium benzoate induced developmental defects, oxidative stress and anxiety-like behaviour in zebrafish larva
ترجمه فارسی عنوان
بنزوات سدیم ناشی از نقص های رشدی، استرس اکسیداتیو و رفتار اضطراب مانند در لارو زرگری است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Sodium benzoate (SB) is a common food preservative. Its FDA described safety limit is 1000 ppm. Lately, increased use of SB has prompted investigations regarding its effects on biological systems. Data regarding toxicity of SB is divergent and controversial with studies reporting both harmful and beneficial effects. Therefore, we did a systematic dose dependent toxicity study of SB using zebrafish vertebrate animal model. We also investigated oxidative stress and anxiety-like behaviour in zebrafish larva treated with SB. Our results indicate that SB induced developmental (delayed hatching), morphological (pericardial edema, yolk sac edema and tail bending), biochemical (oxidative stress) and behavioural (anxiety-like behaviour) abnormalities in developing zebrafish larva. LC50 of SB induced toxicity was approximately 400 ppm after 48 h of SB exposure. Our study strongly supports its harmful effects on vertebrates at increasing doses. Thus, we suggest caution in the excessive use of this preservative in processed and convenience foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 502, Issue 3, 20 July 2018, Pages 364-369
نویسندگان
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