کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8294883 | 1536755 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells
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کلمات کلیدی
p53DDRTLSOXPHOSFluorescence lifetime imaging microscopy (FLIM)FLIM - FL منcisplatin - سیس پلاتینOxidative phosphorylation - فسفوریلاسیون اکسیداتیوOxidative phosphorylation (OXPHOS) - فسفوریلاسیون اکسیداتیو (OXPHOS)NADH - نادانDNA damage response - واکنش به آسیب DNA reduced nicotinamide adenine dinucleotide - کاهش ninocotinamide adenine dinucleotide
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells](/preview/png/8294883.png)
چکیده انگلیسی
Lung cancer is one of the deadliest cancers in the world because of chemo-resistance to the commonly used cisplatin-based treatments. The use of low fidelity DNA polymerases in the translesional synthesis (TLS) DNA damage response pathway that repairs lesions caused by cisplatin also presents a mutational carcinogenic burden on cells that needs to be regulated by the tumor suppressor protein p53. However, there is much debate over the roles of the reversionless 3-like (REV3L) protein responsible for TLS and p53 in regulating cancer cell metabolism. In this study, the fluorescence lifetime of the metabolic coenzyme NADH reveals that the absence of REV3L can promote the p53-mediated upregulation of oxidative phosphorylation in cisplatin-treated H1299 lung carcinoma cells and increases cancer cell sensitivity to this platinum-based chemotherapy. These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 496, Issue 1, 29 January 2018, Pages 199-204
Journal: Biochemical and Biophysical Research Communications - Volume 496, Issue 1, 29 January 2018, Pages 199-204
نویسندگان
Linghao Kong, Michael M. Murata, Michelle A. Digman,