کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8295354 1536758 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tilapia and human CLIC2 structures are highly conserved
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Tilapia and human CLIC2 structures are highly conserved
چکیده انگلیسی
Chloride intracellular channels (CLICs) exist in soluble and membrane bound forms. We have determined the crystal structure of soluble Clic2 from the euryhaline teleost fish Oreochromis mossambicus. Structural comparison of tilapia and human CLIC2 with other CLICs shows that these proteins are highly conserved. We have also compared the expression levels of clic2 in selected osmoregulatory organs of tilapia, acclimated to freshwater, seawater and hypersaline water. Structural conservation of vertebrate CLICs implies that they might play conserved roles. Also, tissue-specific responsiveness of clic2 suggests that it might be involved in iono-osmoregulation under extreme conditions in tilapia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 495, Issue 2, 8 January 2018, Pages 1752-1757
نویسندگان
, , , , ,