کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8296234 | 1536764 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D receptor protects glioblastoma A172Â cells against Coxsackievirus A16 infection induced cell death in the pathogenesis of hand, foot, and mouth disease
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Hand, foot, and mouth disease (HFMD) was one of the most common children illnesses. Coxsackievirus A16 was one of the major pathogens that cause HFMD. However, the role of vitamin D underlying this common illness has not been elucidated. Our study examined that vitamin D levels was significantly lower in 33 HFMD patients, compared to 36 healthy children. Unexpectedly, both mRNA and protein expression of VDR were significantly decreased in CA16 infected glioblastoma A172Â cells. And overexpression of VDR or vitamin D treatment in CA16 infected glioblastoma A172Â cells could reverse the CA16 infection induced cell death, apoptosis or mitochondrial membrane rupture. Therefore, our study, for the first time, demonstrated that vitamin D and VDR could associate with the pathogenesis of HFMD. Thus might provide useful information for HFMD prevention and treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 493, Issue 2, 18 November 2017, Pages 952-956
Journal: Biochemical and Biophysical Research Communications - Volume 493, Issue 2, 18 November 2017, Pages 952-956
نویسندگان
Meiling Qu, Shunxiang Di, Shuyun Zhang, Zhiqun Xia, Guohong Quan,