کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8297235 | 1536775 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combined effect of vascular-leakage-blocker Sac-1004 and antiangiogenic drug sunitinib on tumor angiogenesis
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کلمات کلیدی
PBSFLTfms-like tyrosine kinasePDGFRFITCPFADAPIHUVEC3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromide4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولDMSO - DMSOMTT - MTTOct - اکتبرRET - حقRearranged during transfection - در ترانسفکشن دوباره تنظیم شده استCombination therapy - درمان ترکیبیoptimal cutting temperature - دمای برش مطلوبDimethyl sulfoxide - دیمتیل سولفواکسیدSunitinib - سانیتینیبHuman umbilical vein endothelial cell - سلول اندوتلیالی ورید ناقل انسانیColony-stimulating factor - فاکتور تحریک کننده ColonyVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Phosphate buffered saline - فسفات بافر شورfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتCSF - مایع مغزی نخاعیNormalization - نرمالیزاسیون یا عادی سازیHypoxia - هیپوکسیparaformaldehyde - پارافرمالدهیدplatelet derived growth factor receptor - پلاکت گیرنده فاکتور رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Tumor blood vessels are often leaky because of poor covering by mural cells and loose cell-to-cell contacts. Leaky vessels result in hemorrhage and limited vascular perfusion, which lead to hypoxic tumor microenvironment. Antiangiogenic agents have been shown to normalize the tumor blood vessels, albeit temporarily. Continued administration has been found to be associated with increased tumor hypoxia, a major driving force behind chemoresistance and metastasis. Sac-1004 was recently demonstrated to prevent vascular leakage, normalize tumor vessels and prevent metastasis in sustained manner. Here, we sought that combining antiangiogenic agent, sunitinib with Sac-1004 could have better inhibitory effect upon tumor growth. We found that B16F10 tumor growth was significantly reduced and tumor-bearing mice survival was increased upon combining sunitinib therapy with Sac-1004. In concordance with this observation, tumor vascular perfusion was substantially improved in tumors receiving combination therapy. In addition, tumor vascular leakage was reduced to higher extent in combination treatment group as compared to either therapy alone, an effect attributed to improved vascular junction. Interestingly, hypoxia in tumor environment was significantly reduced, when sunitinib was combined with Sac-1004. Taken together, our data demonstrates that combining antiangiogenic therapy with vascular-leakage inhibiting agent might be a beneficial strategy to combat cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 450, Issue 4, 8 August 2014, Pages 1320-1326
Journal: Biochemical and Biophysical Research Communications - Volume 450, Issue 4, 8 August 2014, Pages 1320-1326
نویسندگان
Keunho Lee, Vijayendra Agrawal, Kyeojin Kim, Jihye Kim, Hyojin Park, Sungwoon Lee, Young-Myeong Kim, Young-Ger Suh, Young-Guen Kwon,