کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8297320 1536776 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagy mediates anti-melanogenic activity of 3′-ODI in B16F1 melanoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Autophagy mediates anti-melanogenic activity of 3′-ODI in B16F1 melanoma cells
چکیده انگلیسی
Autophagy is a cellular degradation process for cellular aggregates and unneeded cellular compartments including damaged mitochondria, ER, and peroxisomes. Melanosome is cellular organelle that is the cellular site of generation, storage and transports of melanin in melanocytes. Despite potential importance of autophagy, the role of autophagy in melanogenesis and melanosome autophagy are largely unknown. In here, we identified 3′-hydroxydaidzein (3′-ODI) as an autophagy inducer from a phytochemical library screening. Treatment with 3′-ODI significantly reduced α-MSH-mediated melanogenesis but efficiently increased autophagy both in melanoma cells and melanocytes. Furthermore, inhibition of autophagy significantly reduced the anti-melanogenic effects of 3′-ODI in α-MSH-stimulated melanoma cells. Taken together, these results suggest that autophagy mediates anti-melanogenic activity of 3′-ODI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 442, Issues 3–4, 13 December 2013, Pages 165-170
نویسندگان
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