Effects of a human plasma membrane-associated sialidase siRNA on prostate cancer invasion

► Neu3 is as one of the sialidases and regulates cell surface functions. ► A Neu3-specific siRNA inhibited prostrate cancer cell invasion and migration. ► The Neu3-specific siRNA inhibited prostate cancer metastasis in mice. ► Targeting Neu3 may have utility for gene-based therapy of human cancer metastasis.