Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells

► Cinnamaldehyde inhibits antigen-induced degranulation of mucosal mast cells. ► The effects of cinnamaldehyde are TRPA1-independent. ► Cinnamaldehyde suppresses antigen-induced Ca2+ influx in mucosal mast cells. ► Cinnamaldehyde attenuates antigen-induced phospholipase Cγ1 phosphorylation in mucosal mast cells.