Reducing blood glucose level in TIDM mice by orally administering the silk glands of transgenic hIGF-I silkworms

► The construction of transgenic expression vector pigA3GFP-fibHS-hIGF-i.e.-neo. ► The transgenic vector was transferred into silkworm eggs by sperm-mediated gene transfer. ► The screen of transgenic silkworm. ► The make of Streptozotocin-induced TIDM mice (Type I diabetes mellitus). ► The estimate of the bioactivity of the expressed hIGF-I in vivo.