Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression

► We studied ligand differences in aryl hydrocarbon receptor-mediated gene expression. ► Greatest differences were among halogenated hydrocarbons and omeprazole. ► We observed ligand and gene-selectivity in coactivator recruitment. ► Residue Y322 of AHR was found to be important for maximal AHR transactivation.