Hypochlorite-modified low-density lipoprotein induces the apoptotic machinery in Jurkat T-cell lines

► HOCl-LDL promotes apoptosis and accumulation of ROS in T-cells. ► Apoptosis occurs via intrinsic routes confirmed by FADDdef or Casp-8def cells. ► Overexpression of Bcl-2 protects T-cells from apoptosis and ROS formation. ► HOCl-modified epitopes colocalize with MPO and T-cells in human placental tissue.