The prokaryotic Mo/W-bisPGD enzymes family: A catalytic workhorse in bioenergetic

► Mo/W-bisPGD enzymes are key components of prokaryotic bioenergetic chains. ► The catalytic mechanisms associated with their functioning is analyzed. ► The large modular variation of their structural organization is highlighted. ► Their interplay with isoprenoid quinones is deciphered. ► Their integration in the biogeochemical N, C and S cycles is reviewed.