Sleep deprivation impairs calcium signaling in mouse splenocytes and leads to a decreased immune response

► Sleep deprivation impairs calcium signaling in mice splenocytes. ► Sleep deprivation results in decrease in calcium stores in endoplasmic reticulum. ► Mitochondrial membrane potential in splenocytes is lost after sleep deprivation. ► Sleep deprivation results in splenocytes lysosomal integrity leakage. ► STIM expression is augmented after sleep deprivation in mice spleen.