The abasic site lesions in the human telomeric sequence d[TA(G3T2A)3G3]: A thermodynamic point of view

► The effects of abasic sites in telomeric quadruplex are sequence-dependent. ► Abasic site lesions decrease the stability of the telomeric quadruplex structure. ► Thermal stability decrease is more evident if the lesion concerns the G-run centre.