کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8301776 | 1537707 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes
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کلمات کلیدی
PALBBRLPCDGAT1,2-diacyl-sn-glycerol - 1،2-دیسیل-اس-گلیسرولBSA - BSAbovine serum albumin - آلبومین سرم گاوAkt - آکتsphingomyelin - اسفنگومیلینBerberine - بربرینTAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولDAG - روزpalmitate - طلاییphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanolamine - فسفاتیدیلتانولامینLysophosphatidylcholine - لیزوفسفاتیدیل کولینprotein kinase B - پروتئین کیناز BGlut-4 - گلوتامین 4glucose transporter-4 - گلوکز حمل کننده-4
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes](/preview/png/8301776.png)
چکیده انگلیسی
In cardiomyocytes insulin binding to its receptor stimulates glucose uptake through the insulin signaling cascade. Palmitate is taken up by cardiomyocytes and converted to palmitoyl-CoA. The palmitoyl-CoA may be used for ATP production through oxidative phosphorylation (OX-PHOS) or combined with glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA) followed by phosphatidic acid (PA). PA is converted to 1,2-diacyl-sn-glycerol (DAG) and then to 1,2,3-triacyl-sn-glycerol (TAG) by 1,2-diacyl-sn-glycerol acyltransferase-2 (DGAT-2). Excess palmitate results in increased DAG production which activates protein kinase C (PKC) which in turn inhibits the insulin signaling cascade. Berberine stimulates glucose uptake through adenosine monophosphate kinase (AMPK) activation of protein kinase B (AKT) and through attenuation of the DAG mediated inhibition of glucose uptake by reducing cellular DAG levels via increasing DGAT-2 expression/activity and reducing TAG hydrolysis.134
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1861, Issue 4, April 2016, Pages 352-362
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1861, Issue 4, April 2016, Pages 352-362
نویسندگان
Wenguang Chang, Li Chen, Grant M. Hatch,