کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8302509 1537737 2013 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids
ترجمه فارسی عنوان
سلولهای سرطانی، پالمیتات اگزوژن را به چربی های سیگنال سازی ساختاری و آن کربن تبدیل می کنند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
De novo lipogenesis is considered the primary source of fatty acids for lipid synthesis in cancer cells, even in the presence of exogenous fatty acids. Here, we have used an isotopic fatty acid labeling strategy coupled with metabolomic profiling platforms to comprehensively map palmitic acid incorporation into complex lipids in cancer cells. We show that cancer cells and tumors robustly incorporate and remodel exogenous palmitate into structural and oncogenic glycerophospholipids, sphingolipids, and ether lipids. We also find that fatty acid incorporation into oxidative pathways is reduced in aggressive human cancer cells, and instead shunted into pathways for generating structural and signaling lipids. Our results demonstrate that cancer cells do not solely rely on de novo lipogenesis, but also utilize exogenous fatty acids for generating lipids required for proliferation and protumorigenic lipid signaling. This article is part of a special issue entitled Lipid Metabolism in Cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1831, Issue 10, October 2013, Pages 1566-1572
نویسندگان
, , , , ,