Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression

► Overexpression of YY1 induces hepatic steatosis in zebrafish. ► YY1 alters the expression of 16 hepatic genes associated with lipid metabolism. ► YY1 induces C/EBP-α and PPAR-γ expression by suppressing CHOP-10 expression. ► Overexpression of YY1 increases the gene expression of de novo FA synthesis. ► Overexpression of YY1 increases hepatic lipotoxicity and liver injury.