Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis

► ABC cholesterol transporters are differentially expressed in neurons and astroglia. ► ABCA1/ABCG1 induction increases cholesterol efflux from glia but not from neurons. ► ABCA1 silencing and inhibition reduce cholesterol efflux from glia but not neurons. ► ABCG1 silencing inhibits cholesterol efflux from astrocytes but not from neurons. ► ABCG4 silencing reduces cholesterol efflux from neurons but not from astrocytes.