A high-fat diet increases l-carnitine synthesis through a differential maturation of the Bbox1 mRNAs

► Bbox1 mRNA maturation involves an alternative polyadenylation process. ► A high fat diet alters the polyadenylation of Bbox1 mRNAs. ► Alternative polyadenylation of Bbox1 affects l-carnitine bioavailability. ► Polyadenylation process can be controlled by the nature of the diet.