Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux

► Cardiac endothelial LPL inversely correlates with plasma triacylglycerol. ► Heart TAG levels do not relate to tissue LPL levels. ► Cardiac ANGPTL4 protein levels increased in response to high plasma lipids. ► LPL in the heart may be controlled to maintain fatty acid flux.