Hepatic metabolism of retinoids and disease associations

► Hepatocytes are responsible for the uptake and processing of postprandial retinoid into the liver. ► Hepatocytes secrete retinol-binding protein (RBP) from the liver and account for most RBP found in the circulation. ► Extrahepatic tissues store retinoid and can recycle this retinoid back to the liver. ► Hepatic stellate cells store more than 50% of all retinoid present in the body. ► Hepatic retinoid stores are lost during the development of hepatic diseases.