Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells

► SPC induces expression of Tgase-2 in time and dose-dependent manner. ► Tgase-2 is involved in SPC-induced Ser 431 phosphorylation of keratin-8. ► JNK activation is dependent on Tgase-2 in SPC-induced Ser 431 phosphorylation.