Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice

► Over-expression of RBP4 leads to insulin resistance and fatty liver in HFD mice. ► RNA oligonucleotide targeted at RBP4 ameliorates metabolic syndrome in HFD mice. ► Anti-RBP4 RNA oligonucleotide reduces liver fat and improves hepatic steatosis.