Apo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors

► Apo-10'-lycopenoic acid displays similarities in term of gene expression with all-trans retinoic acid. ► Apo-10'-lycopenoid acid reduces TNFα and high fat mediated inflammatory response in adipocytes and adipose tissue. ► Apo-10'-lycopenoic acid transactivates RAR in adipose tissue of reporter mice. ► Apo-10'-lycopenoic acid modulates the expression of RAR target genes in vivo.