Trimerized apolipoprotein A-I (TripA) forms lipoproteins, activates lecithin:cholesterol acyltransferase, elicits lipid efflux, and is transported through aortic endothelial cells

► Apolipoprotein A-I (apoA-I) and HDL exert potentially anti-atherogenic properties. ► Trimerized apoA-(TripA) is a potentially therapeutic mimetic of apoA-I and HDL. ► TripA resembles apoA-I by LCAT and cholesterol efflux stimulating properties. ► TripA resembles apoA-I by binding and transport through endothelial cells.