Differential regulation of human apolipoprotein AI and high-density lipoprotein by fenofibrate in hapoAI and hapoAI-CIII-AIV transgenic mice

►Using apoAI- and apoAI-CIII-AIV-transgenic mice we have investigated regulation of fenofibrate-induced regulation of apoAI gene expression in AI and AI-CIII-AIV transgenic mouse lines. ► Fenofibrate up-regulates apoAI gene in apoAI transgenic mice, but not in apoAI-CIII-AIV transgenic mice. ► Cholic acid down-regulates apoAI gene expression both in apoAI and apoAI-CIII-AIV transgenic mice. ► Fenofibrate and cholic acid regulate SR-BI gene expression in opposite direction, which may be partly responsible for circulating levels of HDL-C. ► Fenofibrate up-regulated sterol career protein 2, suggesting increased delivery of cholesterol to the liver. ► Fenofibrate increased HDL size both in the apoAI and AI-CIII-AIV transgenic mice via up-regulation of the PLTP gene.