کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8304921 1538417 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ubiquitination of newly synthesized proteins at the ribosome
ترجمه فارسی عنوان
بستن پروتئین های جدید سنتز شده در ریبوزوم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Newly synthesized proteins can be misfolded or damaged because of errors during synthesis or environmental insults (e.g., heat shock), placing a significant burden on protein quality control systems. In addition, numerous human diseases are associated with a deficiency in eliminating aberrant proteins or accumulation of aggregated proteins. Understanding the mechanisms of protein quality control and disposal pathways for misfolded proteins is therefore crucial for therapeutic intervention in these diseases. Quality control processes function at many points in the life cycle of proteins, and a subset act at the actual site of protein synthesis, the ribosome. Here we summarize recent advances in the role of the ubiquitin proteasome system in protein quality control during the process of translation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 114, July 2015, Pages 127-133
نویسندگان
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