کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8305560 | 1538430 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting of cytosolic mRNA to mitochondria: Naked RNA can bind to the mitochondrial surface
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کلمات کلیدی
GAPDHMTSMDHVDACToMtranslocase of the outer mitochondrial membrane - انتقال از غشای خارجی میتوکندریmitochondrial targeting sequence - توالی هدایت میتوکندریmRNA localization - محلی سازی mRNAmalate dehydrogenase - ملات دهیدروژنازUTR یا untranslated regions - منطقه ترجمه نشدهMitochondria - میتوکندریاProtein targeting - هدف قرار دادن پروتئینvoltage dependent anion channel - کانال آنیونی وابسته به ولتاژPlant - گیاه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Mitochondria contain hundreds of proteins but only a few are encoded by the mitochondrial genome. The other proteins are nuclear-encoded and imported into mitochondria. These proteins can be translated on free cytosolic polysomes, then targeted and imported into mitochondria. Nonetheless, numerous cytosolic mRNAs encoding mitochondrial proteins are detected at the surface of mitochondria in yeast, plants and animals. The localization of mRNAs to the vicinity of mitochondria would be a way for mitochondrial protein sorting. The mechanisms responsible for mRNA targeting to mitochondria are not clearly identified. Sequences within the mRNA molecules (cis-elements), as well as a few trans-acting factors, have been shown to be essential for targeting of some mRNAs. In order to identify receptors involved in mRNA docking to the mitochondrial surface, we have developed an in vitro mRNA binding assay with isolated plant mitochondria. We show that naked mRNAs are able to bind to isolated mitochondria, and our results strongly suggest that mRNA docking to the plant mitochondrial outer membrane requires at least one component of TOM complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 100, May 2014, Pages 159-166
Journal: Biochimie - Volume 100, May 2014, Pages 159-166
نویسندگان
Morgane Michaud, Laurence Maréchal-Drouard, Anne-Marie Duchêne,