A new coumarin derivative plays a role in rhabdoviral clearance by interfering glycoprotein function during the early stage of viral infection

7-(6-(2-methyl-imidazole))-coumarin could interfere SVCV replication inside or outside of cells through two different approaches. Before the process of virus entry into EPC cells, D5 has an impact on SVCV glycoprotein structure so as to disrupt viral binding to the cell surface or translocation to the cytosol. Another strategy for D5 to against SVCV is that, D5 significantly suppresses SVCV-activated autophagy, which is beneficial for the host cells to restrict SVCV viral replication, accompanied by a higher phosphorylation of Akt-mTOR.196