کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8308764 | 1538499 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cadherins in vascular smooth muscle cell (patho)biology: Quid nos scimus?
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کلمات کلیدی
APNAMPKα2CArG boxCa2+iCDC42Bcl2APCbFGFCASCDH - HRCADAM - آدامadenomatosis polyposis coli - آدنوماتوز پولیپوز کولیadiponectin - آدیپونکتینAngiotensin II - آنژیوتانسین دوApoe - آپوapolipoprotein E - آپولیپوپروتئین EAkt - آکتBAD - بدCrk-associated substrate - بستر مرتبط با Crka disintegrin and metalloproteinase - تخریب و متالوپروتئینازAng II - دومbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهB-cell lymphoma 2 - لنفوم سلول B 2Bcl-2-associated death promoter - مرگ و میر مرگبار Bcl-2cell division control protein 42 homolog - پروتئین کنترل تقسیم سلولی 42 همولوگAdherens junction - پیوند پیوندهاIntracellular calcium - کلسیم داخل سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Vascular smooth muscle cells (SMCs) phenotypes span a reversible continuum from quiescent/contractile (differentiated) to proliferative/synthetic (dedifferentiated) enabling them to perform a diversity of functions that are context-dependent and important for vascular tone-diameter homeostasis, vasculogenesis, angiogenesis or vessel reparation after injury. Dysregulated phenotype modulation and failure to maintain/regain the mature differentiated and contractile phenotypic state is pivotal in the development of vascular diseases such as atherosclerosis and restenosis after angioplasty and coronary bypass grafting. Many functions of SMCs such as adhesion, migration, proliferation, contraction, differentiation and apoptosis are regulated by a broad spectrum of cell-cell and cell-matrix adhesion molecules. Cadherins represent a superfamily of cell surface homophilic adhesion molecules with fundamental roles in morphogenetic and differentiation processes during development and in the maintenance of tissue integrity and homeostasis in adults. The cadherins have major inputs on signalling pathways and cytoskeletal assemblies that participate in regulating processes such as cell polarity, migration, proliferation, survival, phenotype and differentiation. Abnormalities in these processes have long been recognized to underlie pathological SMC-driven reparation, but knowledge on the involvement of cadherins is remarkably limited. This article presents a comprehensive review of cadherin family members currently identified on vascular SMCs in relation to their functions, molecular mechanisms of action and relevance for vascular pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 45, May 2018, Pages 23-42
Journal: Cellular Signalling - Volume 45, May 2018, Pages 23-42
نویسندگان
Agne Frismantiene, Maria Philippova, Paul Erne, Therese J. Resink,