کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8310548 | 1538647 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cut-off values to rule out urinary tract infection should be gender-specific
ترجمه فارسی عنوان
مقادیر برش برای جلوگیری از عفونت مجاری ادراری باید به جنس خاص باشد
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The diagnosis of urinary tract infection (UTI) by urine culture is an expensive and time-consuming procedure. Using a screening method, to identify negative samples, would improve the procedure and reduce costs. In this study, urine flow cytometry, of over 7000 urine samples, was assessed by retrospective analysis. With a cut-off value of > 200 bacteria/μl, we obtained a sensitivity of 93.0%, a specificity of 63.5%, and a negative predictive value (NPV) of 96.2%. As a result the culturing of 49% of all samples could be avoided. In addition, the data was retrospectively analyzed to determine if the introduction of gender-specific cut-off values could improve screening results. The obtained receiver operator curves are indeed significantly different when gender specific cut-offs were used. When a NPV of 95% is considered acceptable the unisex cut-off value of > 200 bacteria/μl can be used for women (NPV 94.9%), but the cut-off value for men could be raised to > 400 bacteria/μl without diminishing the NPV (NPV 95.0%).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 452, 15 January 2016, Pages 173-176
Journal: Clinica Chimica Acta - Volume 452, 15 January 2016, Pages 173-176
نویسندگان
N. Geerts, K.J.M. Boonen, A.K. Boer, V. Scharnhorst,